This 2-day ISBA meeting will feature presentations and discussions of topical, frontier research in the methodology and applications of Bayesian statistics, and related areas. The focus areas are among those pioneered by George Box through his career as a path-breaking innovator in concepts, theory, methods and applications across a broad sweep of areas. The workshop is an opportunity to participate in reflecting on Box’s legacy, coupled with the vibrancy of our discipline– especially in its interfaces with challenging areas of application.