This event builds upon a very successful series of previous conferences over the past 25 years. From the first event held in Bath in 1985 to the most recent one held in Birmingham in 2016 being as successful as its predecessors, the organising committee is delighted to announce the 13th IMA International Conference on Mathematics in Signal Processing to be held 18-20 May 2022 at Conference Aston, Birmingham. Signal processing and machine learning constitutes an important area for the application of mathematical concepts and techniques, in an era where learning algorithms must be transparent, robust, explainable and understandable, and ethical. It is a thriving area, as demonstrated by the success of the UK hosting the recent International Conference on Acoustics, Speech, and Signal Processing (ICASSP) in Brighton in 2019. Signal and information processing is at the heart of our technological world, fuelled by developments in, for example, mobile communications, networks and graphs, multimedia systems, medical image analysis, genomics and bioengineering, neural signal processing, big data processing and internet of things. The aim of the conference is to bring together mathematicians, statisticians and engineers with a view to exploring recent developments in mathematics for signal processing and machine learning and identifying fruitful avenues for further research. It is hoped that the meeting will help to attract more mathematicians into this important and challenging field. The conference will follow the same successful format as our previous conferences, comprising tutorials, keynote addresses and non-overlapping technical sessions consisting of oral and poster presentations. A social programme will be organised and will include a reception to welcome delegates. Call for Papers Contributed papers are invited on all aspects of mathematics in signal processing and will be accepted on the basis of a 300‐500 word abstract which should be submitted by 7 January 2022 via https://my.ima.org.uk. The majority of contributed papers will be presented in the poster sessions. Successful authors will be invited to submit a four page paper for inclusion in the conference proceedings by 18 March 2022.