The 21st International Conference on Computational Intelligence Methods for Bioinformatics and Biostatistics (CIBB 2026) will take place in Rome, Italy, on September 2–4, 2026. CIBB is an established international conference series that brings together researchers from statistics, computer science, and life sciences to explore advanced computational and data-driven approaches for biomedical research. Topics include machine learning, artificial intelligence, biostatistics, bioinformatics, medical informatics, and large-scale analysis of biological and clinical data. The conference focuses on cutting-edge methods for understanding complex biological systems, improving disease modeling, and enabling data-driven healthcare and precision medicine. Special attention is given to emerging paradigms such as high-performance computing, scalable algorithms, and quantum-inspired approaches for life sciences. CIBB fosters interdisciplinary collaboration between academia and industry, providing a forum for presenting original research, discussing emerging challenges, and promoting innovative solutions at the intersection of AI and health.