After five groundbreaking conferences at Penn State, Statistical Challenges in Modern Astronomy VI will be held at Carnegie Mellon University, June 6 to 10, 2016. This meeting will continue the interdisciplinary tradition of its predecessors, bringing together researchers in astronomy, cosmology, statistics, and machine learning to facilitate progress on the significant data analysis challenges that result from current and future astronomical sky surveys. Abstracts will be accepted for contributed talks and for posters.