Chair: Larry Wasserman, Carnegie Mellon University Panelists: Deborah Mayo, Virginia Tech, Karen Kafadar, University of Virginia, Ya’acov Ritov, University of Michigan, Stanley Young, CGStat (JSM Virtual Panel: 10-11:50 AM) ABSTRACT: In the face of today’s crisis of replication, researchers, societies, and journals are advancing methodological reforms. Many are welcome, others are radical. The misuses of statistical significance tests and P-values have resulted in the most criticism. The time is right to consider the presuppositions of criticisms, the ramifications of proposed reforms, and set the stage for a balanced appraisal of alternative methods. Our overall aim is to point to new avenues for communicating the proper interpretation of P-values, and to ensure our theoretically sound statistical methodology is neither abused nor dismissed categorically.