Infectious disease models have a long history in human epidemiology, but only more recently have been applied to domestic or wildlife host species. These models offer a way to test response plans, evaluate detection methods, identify effective methods to mitigate disease, and answer policy questions. Given that many diseases of current and future concern have both wild and domestic animal components, a need exists to understand the strengths and weaknesses of current modeling frameworks to capture the dynamics both within and between wild and domestic hosts. Enhanced collaboration across institutions and among biologists, modelers, and veterinarians is needed to reduce the risks posed by animal-related diseases. Through this workshop, we seek to develop a better understanding of the availability and utility of different kinds of modeling approaches as well as the data to answer complex questions.